What were the most significant obstacles to establishing colonial rule over native peoples in Mexico and/or the Andes between 1521 and 1579? Be specific

First Response paper: Choose one of the following questions and write a three page essay, drawing on material from the lectures and assigned readings. Completed assignments are due Monday, March 27, 5:00 pm. What were the most significant obstacles to establishing colonial rule over native peoples in Mexico and/or the Andes between 1521 and 1579? […]